Many violinists truly believe that these instruments are better than newly made violins, and several scientists have tried to work out why. Some suspected at the unusually dense wood, harvested from Alpine spruces that grew during an Ice Age. Others pointed the finger at the varnish, or the chemicals that Stradivari used to treat the wood.
The proposed rule provides additional guidance to manufacturers regarding how to calculate this ceiling price, and would require manufacturers to calculate the price on a quarterly basis using the AMP for the smallest unit of measure minus the Unit Rebate Amount URA to six decimal places.
HRSA will publish the ceiling price, presumably on a quarterly basis, rounded to two decimal places. The rebate percentage is limited to percent of the AMP, such that the B price will never be negative. HRSA also proposes to codify previously issued guidelines for calculating the ceiling price of new drugs for which AMP data is not yet available.
By the end of the fourth quarter, manufacturers must refund or credit any difference between the actual and estimated ceiling prices to covered entities that purchased the drug during the first three quarters.
This includes any order placed directly with a manufacturer or through a wholesaler, authorized distributor, or agents. The regulation applies only to manufacturers even though wholesalers and other entities have a role in the discount process.
Under ACA sectionHRSA is to publish ceiling prices on its website in a way that limits access to covered entities and protects privileged data from unauthorized re-disclosure.
However, although the proposed regulations provide for the publication of ceiling prices, HRSA gives no further detail on how it will ensure the confidentiality of published data. The proposed rule would eliminate the section of the rules regarding the exclusion of orphan drugs from the definition of a covered outpatient drug, apparently in response to a federal district court decision vacating the provision.
After PhRMA vacated the final orphan drug rule, HRSA released an interpretive rule stating that the decision had not invalidated its interpretation of the orphan drug exclusion and describing how HRSA planned to interpret and implement the exclusion.Comment by valanthor Excellent guide for the most part, however some things are wrong (as of PTR build ).
Ships are like followers when using retraining items: ship crews are like follower traits and a ship's equipment is like a follower's abilities. The HIV P24 antigen is a small piece of protein that is found on the capsule of the HIV virus.
When a person is infected with HIV, these bits of protein can be found floating in the blood. Abstract. The proper understanding and use of statistical tools are essential to the scientific enterprise. This is true both at the level of designing one's own experiments as well as for critically evaluating studies carried out by others.
That seems different, though, because it requires rejecting one ideology/ingroup, namely Catholicism. It makes sense that people identifying as Catholic would resent that the Protestants found a way to weaken Catholicism, and apparently people who “took the soup” were ostracized.
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